Fred Wesley (born 1943) is an American jazz and funk trombonist, best known for his work with James Brown in the 1960s and 1970s. Wesley was born in Mobile, Alabama, the son of a high school teacher and big band leader. During the 1960s and 1970s he was a pivotal member of James Brown's bands, playing on many hit recordings including "Say it Loud - I'm Black and I'm Proud", "Mother Popcorn" and co-writing tunes such as "Hot Pants". His slippery riffs and pungent, precise solos, complementing those of saxophonist Maceo Parker, gave Brown's R&B, soul, and funk tunes their instrumental punch.

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