Frank Rosolino (August 20, 1926 - November 26, 1978) was an American jazz trombonist.

Born in Detroit, Michigan, in a family that included brothers Russell and Gasper, Rosolino studied the guitar with his father starting at age 9. Frank took up the trombone at age 14, and graduated from Miller High School, while playing in the Cass Tech Symphony Orchestra, a fine music program that also produced Donald Byrd. Following service in the U.S. Army's 86th Division during World War II, he played with the big bands of Bob Chester, Glen Gray, Tony Pastor, Herbie Fields, and Gene Krupa. He became famous during a stint in the most popular of Stan Kenton's progressive big bands, (1952-1954), and settled in Los Angeles, where he worked with everybody in the business: Howard Rumsey's Lighthouse All-Stars (1954-1960), Terry Gibbs, Shorty Rogers, Benny Carter, Buddy Rich, Dexter Gordon, Carl Fontana, Jean "Toots" Thielmans, Stan Levey, Shelly Manne, Pete Christlieb, Bobby Knight, Conte Candoli, Med Flory, Donn Tremmer, Mel Tormé, Louis Bellson, Marty Paich, Zoot Sims, Quincy Jones, and Tutti Camarata. He attempted to maintain his popularity in the 1970s through high-profile associations with non-jazz bands, including Tower of Power and Brass Machine, but most fans remember this period in his career through his association with Med Flory's Supersax.

Frank's third wife, and the mother of their two sons, committed suicide in February 1972 in Los Angeles, California, and he was overheard telling his girlfriend that her suicide forced him to contemplate his own death. He died in 1978 in Van Nuys, California, committing suicide after shooting both sons, Justin, 9, and Jason, 7, his only children. Jason survived, blinded, and was adopted by his mother's cousin, Claudia Eien, and her husband Gary.

The International Trombone Association established its first award for jazz trombone in Frank's memory, and he continues to be remembered as one of the greatest jazz trombone players of all time.

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