Old Crow Medicine Show is a folk/country group from Nashville, Tennessee. Along with original songs, the band performs many pre-World War II blues and folk songs. The style of music they perform is sometimes called alt-country, but today more often referred to as Americana.

Their 2004 album "O.C.M.S." was selected by CMT (Country Music Television) as one of the top-10 bluegrass albums of that year. Their current tour includes bars, festivals, and larger venues. They are best experienced in smaller settings, where their infectious high-energy style electrifies the crowd, often a mixture of older listeners and 20-somethings.

They make frequent guest appearances on A Prairie Home Companion.

The song Wagon Wheel is written based off a chorus composed by Bob Dylan for the film Pat Garrett and Billy the Kid.

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